Cartílago
Role of Platelet-Rich Plasma in Articular Cartilage Injury and Disease – Por Randy Mascarenhas, Bryan M. Saltzman, Lisa A. Fortier, y Brian J. ColeEnhanced Marrow Stimulation Techniques – Por Rachel M. Frank, MD; Kai Mithoefer, MD; Sanjeev Bhatia, MD; y Brian J. Cole, MD, MBAThe Anti-inflammatory and Matrix Restorative Mechanisms of Platelet-Rich Plasma in Osteoarthritis – En he American Journal of Sports Medicine, por Emily A. Sundman, Brian J. Cole, Vasili Karas, Craig Della Valle, Mathew W. Tetreault, Hussni O. Mohammed and Lisa A. FortierCurrent Concepts: The Role of Mesenchymal Stem Cells in the Management of Knee Osteoarthritis – En Sports Health, por Jesse I. Wolfstadt, Brian J. Cole, Darrell J. Ogilvie-Harris, Sowmya Viswanathan y Jaskarndip Chahal
Células Madre
BMC Injection Articles
Autologous Bone Marrow Concentrate: Review and Application of a Novel Intra-Articular Orthobiologic for Cartilage Disease – Sampson S, Botto-Van Bemden A, Aufiero D, The Physician and Sports Medicine. 2013 SepClinical Outcome of Autologous Bone Marrow Aspirates Concentrate Injection in Degenerative Arthritis of the Knee – Jae-Do Kim, Gun Woo Lee, Gu Hee Jung, Cheung Kue Kim, Taehun Kim, Jin Hyung Park, Seong Sook Cha, Young-Bin Yoo – European journal of Orthopaedic Surgery and Traumatology. 2014 JanRegenerative injection therapy with whole bone marrow aspirate for degenerative joint disease: a case series. – Hauser RA, Orlofsky A., Clin Med Insights Arthritis Musculoskelet Disord. 2013 Sep 4Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics. – Filardo G, Madry H, Jelic M, Roffi A, Cucchiarini M, Kon E. – Knee Surg Sports Traumatol Arthrosc. 2013 Jan 11.Impacts of bone marrow aspirate and peripheral blood derived platelet-rich plasma on the wound healing in chronic ischaemic limb. – Nishimoto S, Kawai K, Tsumano T, Fukuda K, Fujiwara T, Kakibuchi M. – J Plast Surg Hand Surg. 2013 Apr 26.Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followup. – Pascual-Garrido C, Rolón A, Makino A. – Stem Cells Int. 2012;2012:953510. doi: 10.1155/2012/953510. Epub 2011 Dec 18.Effects of intra-articular administration of autologous bone marrow aspirate on healing of full-thickness meniscal tear: an experimental study on sheep. – Duygulu F, Demirel M, Atalan G, Kaymaz FF, Kocabey Y, Dülgeroğlu TC, Candemir H. – Acta Orthop Traumatol Turc. 2012;46(1):61-7.Clinical Use of Bone Marrow, Bone Marrow Concentrate, and Expanded Bone Marrow Mesenchymal Stem Cells in Cartilage Disease. – Veronesi F, Giavaresi G, Tchon M, Borsari V, Nicoli Aldini N, Fini M. – Stem Cells Dev. 2012 Nov 16. PMID: 23030230Establishing proof of concept: Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus – Niall A Smyth, Christopher D Murawski, Amgad M Haleem, Charles P Hannon, Ian Savage-Elliott, John G Kennedy – World J Orthop 2012 July 18; 3(7): 101-108Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy. – Kevin J. Campbell, Robert E. Boykin, Coen A. Wijdicks, J. Erik Giphart, Robert F. LaPrade, Marc J. Philippon – Knee Surg Sports Traumatol Arthrosc.
Terapias regenerativas
Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cells. – Hernigou P, Homma Y, Flouzat Lachaniette CH, Poignard A, Allain J, Chevallier N, Rouard H. – Int Orthop. 2013 Jul 24.Safety of autologous bone marrow aspiration concentrate transplantation: initial experiences in 101 patients. – Christian Hendrich, Engelmaier Franz, Gerhart Waertel, Rolf Krebs, and Marcus Jager. – Orthop Rev (Pavia). 2009 October 10; 1(2): e32. Doi: 10.4081/or.2009.e32Stem cells and cartilage development: complexities of a simple tissue. – Hollander AP, Dickinson SC, Kafienah W – Stem Cells 2010, 28:1992-1996.Cartilage tissue engineering: towards a biomaterial assisted mesenchymal stem cell therapy. – Vinatier C, Bouffi C, Merceron C, Gordeladze J, Brondello JM, Jorgensen C, Weiss P, Guicheux J, Noel D – Curr Stem Cell Res Ther 2009, 4:318-329.Chondrogenesis and cartilage tissue engineering: the longer road to technology development. – Mahmoudifar N, Doran PM – Trends Biotechnol 2012, 30:166-176 Concise Review: The Clinical Application of Mesenchymal Stem Cells for Musculoskeletal Regeneration: Current Status and Perspectives. – Andre F. Steinart, Lars Rackwitz, Fabian Gilbert, Ulrich Noth, Rocky S Tuan – Stem Cells Translational Medicine 2012; 1:237-247Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. – Hass R, Kasper C, Bohm S, Jacobs R – Cell Commun Signal 2011, 9:12Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. – Caplan AI – J Cell Physiol 2007, 213:341-347.Marrow stromal cells as stem cells for nonhematopoietic tissues. – Prockop DJ – Science 1997, 276:71-74.The Vertibral Interbody Grafting Site’s Low Concentration in Osteogenic Progenitors can Greatly Benefit from Addition of Iliac Crest Bone Marrow – Romih, et al – European Spine Journal; 14:645-648; 2005Cartilage in health and disease. In Arthritis and Allied conditions: A Textbook of Rheumatology. 13th edition. Edited by Koopman WS. Baltimore – Poole AR – Lipincott Williams and Wilkins; 1997: 255-308
Multilineage potential of adult human mesenchymal stem cells. – Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR – Science 1999,284:143-147.A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. – Wynn RF, Hart CA, Corradi-Perini C, O’Neill L, Evans CA, Wraith JE, Fairbairn LJ, Bellantuono I – Blood 2004, 104:2643-2645.
Osteoartritis
Establishing proof of concept: Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus -Niall A Smyth, Christopher D Murawski, Amgad M Haleem, Charles P Hannon, Ian Savage-Elliott, John G Kennedy – World J Orthop 2012 July 18; 3(7): 101-108Treatment of a hip capsular injury in a professional soccer player with platelet-rich plasma and bone marrow aspirate concentrate therapy. – Kevin J. Campbell, Robert E. Boykin, Coen A. Wijdicks, J. Erik Giphart, Robert F. LaPrade, Marc J. Philippon. – Knee Surg Sports Traumatol Arthrosc.Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. – Goldring MB, Goldring SR – Ann N Y Acad Sci 2010, 1192:230-237.The impact of osteoarthritis: implications of research. – Buckwalter JA, Saltzman C, Brown T – Clin Orthop Relat Res 2004, (427 Suppl):S6-S15Stem cell therapy for cartilage regeneration in osteoarthritis. – Koelling S, Miosge N – Expert Opin Biol Ther 2009, 9:1399-1405.Future Directions for Research and Treatments of Osteoarthritis – Charles J. Malemud and Victor M. Goldberg – Frontiers in Bioscience 4, d762-771, October 15, 1999Intraarticular treatments for osteoarthritis: new perspectives – Chevalier X – Curr Drug Targets 2010, 11:546-560.Mesenchymal stem cells for cartilage repair in osteoarthritis. – Pawan K. Gupta, Anjan K. Das, Anoop Chullikana and Anish S. Majumdar – Stem Cell Research & Therapy 2012, 3:25 doi: 10.1186/scrt116Mesenchymal stem cells in arthritic diseases. – Chen FH, Tuan RS – Arthritis Res Ther 2008, 10:223.Mesenchymal stem-cell based HLA-independent cell therapy for tissue engineering of bone and cartilage. – Niemeyer P, Krause U, Kasten P, Kreuz PC, Henle P, Sudkam NP, Mehlhorn A – Curr stem Cell Res Ther 2006, 1:21-27Stem Cells and other innovative intra-articular therapies for osteoarthritis: What does the future hold? – Singh A Jasvinder – BMC Medicine 2012, 10:44Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. – Wakitani S, Nawata M, Tensho K, Okabe T, Machida H, Ohgushi H – J Tissue Eng Regen Med 2007, 1:74-79Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. – Nejadnik H, Hui JH, Feng Choong EP, Tai B-C, Lee EH – Am J Sports Med 2010, 38:1110-1116.Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. – Davatchi F, Abdollahi BS, Mohyeddin M, Shahram F, Nikbin B – Int J Rheum Dis 2011, 14:211-215.Intra-articular injection of Autologous Mesenchymal Stem Cells in Six patients with Knee Osteoarthritis – Mohsen Emadedin MD, Naser Aghdmani MD PhD, Leilar Taghiyar MSc, Roghayeh Fazeli MD, Reza Moghadasali MSc, et al – Arch Iran Med. 2012; 15(7): 422-428.Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two case report. – Kasemkijwattana C, Hongeng S, Kesprayura S, Rungsinaporn V, Chaipinyo K, Chansiri K – J Med Assoc Thai 2011, 94:395-400.Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. – Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D – Pain Physician 2008, 11:343-353.
Cadera
Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series. – Pak J – J Med Case Rep 2011, 5:296.Treatment of osteonectrosis of the femoral head with implantation of autologous bone-marrow cells: A pilot study – Gangji V, Hauzeur JP, Matos C, De Maertelaer V, Toungouz M, Lambermont M. – J Bone Joint Surg Am. 2004 Jun; 86-A(6):1153-60.Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells. – Kuroda R, Ishida K, Matsumoto T, Akisue T, Fujioka H, Mizuno K, Ohgushi H, Wakitani S, Kurosaka M – Osteoarthr Cartil 2007, 15:226-231.The clinical use of human culture-expanded autologous bone marrow mesenchymal stem cells transplanted on platelet-rich fibrin glue in the treatment of articular cartilage defects: a pilot study and preliminary results. – Haleem AM, Singergy AAE, Sabry D, Atta HM, Rashed LA, Chu CR, El Shewy MT, Azzam A, Abdel Aziz MT – Cartilage 2010, 1:253-261.
Curación de hueso
Bone marrow aspirate and bone allograft to treat acetabular bone defects in revision total hip arthroplasty: preliminary report. – Vulcano E, Murena L, Falvo DA, Baj A, Toniolo A, Cherubino P. – Eur Rev Med Pharmacol Sci. 2013 Aug;17(16):2240-9.Regenerate Augmentation with bone marrow concentrate after traumatic bone loss. – Gessman J, Koller M, Godry H, Schildhaur T, Seyhold D, Department of General and Trauma Surgery and Department of Surgical Research, BG University Hospital – Orthopedic Reviews 2012; volume 4:e14Percutaneous Autologous Bone-Marrow Grafting for Nonunions: Influence of the Number and Concentration of Progenitor Cells. – Ph. Hernigou, MD; A. Poignard, MD; F. Beaujean, MD; H. Rouard, MD. – The Journal of Bone and Joint Surgery. 2005; 87:1430-1437
Isquemia de extremidades
Modelo animal
STEM CELL THERAPY FOR TENDINOPATHY: LESSONS FROM A LARGE ANIMAL MODEL – R K W Smith – Br J Sports Med 2013;47:e2 doi:10.1136/bjsports-2013-092459.42Autologous bone marrow mesenchymal stromal cells for regeneration of injured equine ligaments and tendons: A clinical report. – Renzi S, Riccò S, Dotti S, Sesso L, Grolli S, Cornali M, Carlin S, Patruno M, Cinotti S, Ferrari M. – Res Vet Sci. 2013 Feb 16. pii: S0034-5288(13)00019-2. doi: 10.1016/j.rvsc.2013.01.017Homing and reparative effect of intra-articular of autologous mesenchymal stem cells in osteoarthritis animal model. – Mokbel AN, El Tookhy OS, Shamaa AA, Rashed LA, Sabry D, El Sayed AM. – BMC Musculoskelet Disord. 2011 Nov 15; 12:259.Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis. – Sato M, Uchida K, Nakajima H, Miyazaki T, Guerrero AR, Watanabe S, Roberts S, Baba H. – Arthritis Res Ther. 2012 Feb 7;14(1):R31Cell based therapy for osteoarthritis in a sheep model: gross and histological assessment. – Alfaqeh H, Norhamdan MY, Chua KH, Chen HC, Aminuddin BS, Ruszymah BH – Med J Malaysia 2008, 63(Suppl A):37-38.Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit. – Grigolo B, Lisignoli G, Desando G, Cavallo C, Marconi E, Tschon M, Giavaresi G, Fini M, Giardino R, Facchini A – Tissue Eng Part C Methods 2009, 15:647-658.Stem cell therapy in a caprine model of osteoarthritis. – Murphy JM, Fink DJ, Hunziker EB, Barry FP – Arthritis Rheum 2003, 48:3464-3474.The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs. – Wang W, Li B, Yang J, Xin L, Li Y, Yin H, Qi Y, Jiang Y, Ouyang H, Gao C – Biomaterials 2010, 31:8964-8973Bone marrow mesenchymal stem cells inhibit the response of naïve and memory antigen-specific T cells to their cognate peptide. – Mauro Krampera, Sarah Glennie, Julian Dyson, Diane Scott, Ruthline Laylor, Elizabeth Simpson, and Francesco Dazzi. – Blood May 1, 2003 vol. 101 no. 9 3722-3729Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs – Connelly JT, Wilson CG, Levenston ME – Osteoarthr Cartil 2008, 16:1092-1100.Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model. – Fortier LA, Potter HG, Rickey EJ, Schnabel LV, Foo LF, Chong LR, Stokol T, Cheetham J, Nixon AJ. – J Bone Joint Surg Am. 2010 Aug 18; 92(10):1927-37The role of pharmacologically active microcarriers releasing TGF-beta3 in cartilage formation in vivo by mesenchymal stem cells. – Bouffi C, Thomas O, Bony C, Giateau A, Venier-Julienne MC, Jorgensen C, Montero-Menei C, Noel D – Biomaterials 2010, 31:6485-6493.
Células mesenquimales
Subcutánea de G-CSF para la angiogénesis
Médula ósea in vitro (estudios de laboratorio)
Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. – Barry F, Boynton RE, Liu B, Murphy JM – Exp Cell Res 2001, 268:189-200.Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. – Sekiya I, Larson BL, Vuoristo JT, Reger RL, Prockop DJ – Cell Tissue Res 2005, 320:269-276.
Chemokine receptor CXCR4-dependent inernalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. – Dar A, Goichberg P, Shinder V, Kalinkovich A, Kollet O, Netzer N, Margalit R, Zsak M, Nagler A, Hardan I, Resnick I, Rot A, Lapidot T – Nat Immunol 2005, 6:1038-1046